Assay Detail
Binding
CHEMBL3816884
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid from full length human TNNI3K expressed in baculovirus system incubated for 60 mins by fluorescence polarization assay
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase TNNI3K (CHEMBL5260) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
GSK114: A selective inhibitor for elucidating the biological role of TNNI3K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.35 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3814998 | — | — | 1 | 7.89 |
| CHEMBL3813957 | — | — | 1 | 7.89 |
| CHEMBL3814010 | — | — | 1 | 7.80 |
| CHEMBL3815093 | — | — | 1 | 7.60 |
| CHEMBL3814442 | — | — | 1 | 7.60 |
| CHEMBL3814635 | — | — | 1 | 7.60 |
| CHEMBL3815116 | — | — | 1 | 7.60 |
| CHEMBL3612666 | — | — | 1 | 7.50 |
| CHEMBL3612665 | — | — | 1 | 7.50 |
| CHEMBL3814121 | — | — | 1 | 7.50 |
| CHEMBL3612661 | — | — | 1 | 7.40 |
| CHEMBL3813872 | — | — | 1 | 7.40 |
| CHEMBL3612667 | — | — | 1 | 7.40 |
| CHEMBL3613195 | — | — | 1 | 7.30 |
| CHEMBL3813902 | — | — | 1 | 7.30 |
| CHEMBL3814727 | — | — | 1 | 7.20 |
| CHEMBL3613177 | — | — | 1 | 7.20 |
| CHEMBL3813871 | — | — | 1 | 7.10 |
| CHEMBL3612647 | — | — | 1 | 7.10 |
| CHEMBL3612664 | — | — | 1 | 6.89 |
| CHEMBL3814685 | — | — | 1 | 6.89 |
| CHEMBL3814515 | — | — | 1 | 6.70 |
| CHEMBL3814179 | — | — | 1 | 6.70 |
| CHEMBL3814798 | — | — | 1 | - |
| CHEMBL3814871 | — | — | 1 | - |
| CHEMBL3814923 | — | — | 1 | - |
| CHEMBL3814834 | — | — | 1 | - |
| CHEMBL3813948 | — | — | 1 | - |
| CHEMBL3814097 | — | — | 1 | - |
| CHEMBL3613305 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3814998 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3813957 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3814010 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3815093 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3814442 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3814635 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3815116 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3612666 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3612665 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3814121 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL3612661 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3813872 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3612667 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3613195 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3813902 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3814727 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3613177 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3813871 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3612647 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL3612664 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3814685 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL3814515 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3814179 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL3814798 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL3814871 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL3814923 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL3814834 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL3813948 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL3814097 | — | IC50 | < | 10.0 | nM | - |
| CHEMBL3613305 | — | IC50 | < | 10.0 | nM | - |