Assay Detail
Binding
CHEMBL3816945
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant SphK1 using sphingosine as substrate incubated for 20 mins by scintillation counting analysis in presence of [gamma-32P]ATP
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.53 | 6.14 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3814505 | — | — | 1 | 6.14 |
| CHEMBL3814234 | — | — | 1 | 6.03 |
| CHEMBL3813833 | — | — | 1 | 5.14 |
| CHEMBL3416830 | — | — | 1 | 4.80 |
| CHEMBL3813772 | — | — | 1 | - |
| CHEMBL3814849 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3814505 | — | Ki | = | 730.0 | nM | 6.14 |
| CHEMBL3814234 | — | Ki | = | 930.0 | nM | 6.03 |
| CHEMBL3813833 | — | Ki | = | 7200.0 | nM | 5.14 |
| CHEMBL3416830 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL3813772 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL3814849 | — | Ki | > | 20000.0 | nM | - |