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Assay Detail

CHEMBL3816951

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of SphK1 in mouse erythrocytes using sphingosine as substrate by luminescence assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Mus musculus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sphingosine kinase 1 (CHEMBL2401605)
Type SINGLE PROTEIN
Organism Mus musculus

Publication

Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors.
Congdon MD, Kharel Y, Brown AM, Lewis SN, Bevan DR, Lynch KR, Santos WL.
ACS Med Chem Lett (2016) 7 : 229 -234
PubMed 26985306 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.44 8.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3134157 1 8.44

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3134157 Ki = 3.6 nM 8.44