Assay Detail
Binding
CHEMBL3816952
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Inhibition of human myc-tagged TNNI3K autophosphorylation overexpressed in HEKMSR2 cells incubated for 30 mins by time resolved fluorescence assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEKMSR2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase TNNI3K (CHEMBL5260) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
GSK114: A selective inhibitor for elucidating the biological role of TNNI3K.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.22 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3814834 | — | — | 1 | 8.00 |
| CHEMBL3813948 | — | — | 1 | 7.89 |
| CHEMBL3814871 | — | — | 1 | 7.60 |
| CHEMBL3814923 | — | — | 1 | 7.60 |
| CHEMBL3613195 | — | — | 1 | 7.30 |
| CHEMBL3814010 | — | — | 1 | 7.30 |
| CHEMBL3814998 | — | — | 1 | 7.30 |
| CHEMBL3814097 | — | — | 1 | 7.20 |
| CHEMBL3813957 | — | — | 1 | 7.10 |
| CHEMBL3815093 | — | — | 1 | 7.00 |
| CHEMBL3814635 | — | — | 1 | 6.80 |
| CHEMBL3814442 | — | — | 1 | 6.50 |
| CHEMBL3815116 | — | — | 1 | 6.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3814834 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3813948 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3814871 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3814923 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3613195 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3814010 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3814998 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL3814097 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL3813957 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL3815093 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL3814635 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL3814442 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL3815116 | — | IC50 | = | 500.0 | nM | 6.30 |