Assay Detail
Binding
CHEMBL3817030
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Displacement of [3H]TO901317 from LXRalpha ligand binding domain (unknown origin) after 30 mins by liquid scintillation counting
14
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.85 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3814501 | — | — | 1 | 8.52 |
| CHEMBL3814006 | — | — | 1 | 7.70 |
| CHEMBL3814153 | — | — | 1 | 7.60 |
| CHEMBL3815014 | — | — | 1 | 7.37 |
| CHEMBL3814206 | — | — | 1 | 7.09 |
| CHEMBL3815001 | — | — | 1 | 6.84 |
| CHEMBL3814478 | — | — | 1 | 6.80 |
| CHEMBL3813863 | — | — | 1 | 5.97 |
| CHEMBL3813875 | — | — | 2 | 5.96 |
| CHEMBL3814372 | — | — | 3 | 5.66 |
| CHEMBL3815113 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3814501 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL3814006 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL3814153 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL3815014 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL3814206 | — | Ki | = | 81.0 | nM | 7.09 |
| CHEMBL3815001 | — | Ki | = | 146.0 | nM | 6.84 |
| CHEMBL3814478 | — | Ki | = | 157.0 | nM | 6.80 |
| CHEMBL3813863 | — | Ki | = | 1072.0 | nM | 5.97 |
| CHEMBL3813875 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL3813875 | — | Ki | = | 1552.0 | nM | 5.81 |
| CHEMBL3814372 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL3814372 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL3814372 | — | Ki | > | 3300.0 | nM | - |
| CHEMBL3815113 | — | Ki | - | — | - |