Assay Detail
Binding
CHEMBL3817032
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Agonist activity at human LXRalpha ligand binding domain(167 to 447 residues) transfected in HEK293 cells after 16 hrs by Gal4-luciferase reporter gene assay
14
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.17 | 7.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3814501 | — | — | 1 | 7.04 |
| CHEMBL3814006 | — | — | 1 | 6.69 |
| CHEMBL3814206 | — | — | 1 | 6.61 |
| CHEMBL3815014 | — | — | 1 | 6.59 |
| CHEMBL3814153 | — | — | 1 | 6.59 |
| CHEMBL3815001 | — | — | 1 | 6.23 |
| CHEMBL3814478 | — | — | 1 | 6.12 |
| CHEMBL3813863 | — | — | 1 | 5.76 |
| CHEMBL3814372 | — | — | 3 | 5.60 |
| CHEMBL3813875 | — | — | 2 | 5.42 |
| CHEMBL3815113 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3814501 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL3814006 | — | EC50 | = | 205.0 | nM | 6.69 |
| CHEMBL3814206 | — | EC50 | = | 244.0 | nM | 6.61 |
| CHEMBL3815014 | — | EC50 | = | 257.0 | nM | 6.59 |
| CHEMBL3814153 | — | EC50 | = | 254.0 | nM | 6.59 |
| CHEMBL3815001 | — | EC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3814478 | — | EC50 | = | 763.0 | nM | 6.12 |
| CHEMBL3813863 | — | EC50 | = | 1734.0 | nM | 5.76 |
| CHEMBL3814372 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3813875 | — | EC50 | = | 3825.0 | nM | 5.42 |
| CHEMBL3814372 | — | EC50 | = | 5375.0 | nM | 5.27 |
| CHEMBL3814372 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3815113 | — | EC50 | > | 20000.0 | nM | - |
| CHEMBL3813875 | — | EC50 | > | 10000.0 | nM | - |