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Assay Detail

CHEMBL3817352

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antimalarial activity against Plasmodium falciparum 3D7 incubated for 72 hours by DAPI-staining based confocal imaging analysis
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Selective anti-malarial minor groove binders.
Scott FJ, Khalaf AI, Duffy S, Avery VM, Suckling CJ.
Bioorg Med Chem Lett (2016) 26 : 3326 -3329
PubMed 27212070 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 34 6.06 8.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL269671 ARTEMISININ 3.0 1 8.11
CHEMBL36 PYRIMETHAMINE 4.0 1 8.07
CHEMBL76 CHLOROQUINE 4.0 1 7.95
CHEMBL95965 1 7.41
CHEMBL469912 PUROMYCIN 2.0 1 7.22
CHEMBL236563 1 6.99
CHEMBL3799766 1 6.49
CHEMBL396361 1 6.46
CHEMBL395187 1 6.41
CHEMBL237235 1 6.36
CHEMBL3814766 1 6.33
CHEMBL126486 1 6.26
CHEMBL394275 1 6.11
CHEMBL394377 1 6.06
CHEMBL391515 1 5.85
CHEMBL235083 1 5.75
CHEMBL3798709 1 5.75
CHEMBL3798543 1 5.71
CHEMBL236564 1 5.71
CHEMBL3797790 1 5.70
CHEMBL3814229 1 5.56
CHEMBL3798328 1 5.52
CHEMBL3800015 1 5.48
CHEMBL3798718 1 5.48
CHEMBL3800571 1 5.47
CHEMBL3798376 1 5.45
CHEMBL3798852 1 5.37
CHEMBL3797620 1 5.33
CHEMBL3814528 1 5.26
CHEMBL3797456 1 5.22

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL269671 ARTEMISININ IC50 = 7.75 nM 8.11
CHEMBL36 PYRIMETHAMINE IC50 = 8.45 nM 8.07
CHEMBL76 CHLOROQUINE IC50 = 11.35 nM 7.95
CHEMBL95965 IC50 = 39.0 nM 7.41
CHEMBL469912 PUROMYCIN IC50 = 60.0 nM 7.22
CHEMBL236563 IC50 = 103.0 nM 6.99
CHEMBL3799766 IC50 = 322.0 nM 6.49
CHEMBL396361 IC50 = 350.0 nM 6.46
CHEMBL395187 IC50 = 390.0 nM 6.41
CHEMBL237235 IC50 = 437.0 nM 6.36
CHEMBL3814766 IC50 = 469.0 nM 6.33
CHEMBL126486 IC50 = 544.0 nM 6.26
CHEMBL394275 IC50 = 780.0 nM 6.11
CHEMBL394377 IC50 = 868.0 nM 6.06
CHEMBL391515 IC50 = 1409.0 nM 5.85
CHEMBL235083 IC50 = 1766.0 nM 5.75
CHEMBL3798709 IC50 = 1800.0 nM 5.75
CHEMBL3798543 IC50 = 1926.0 nM 5.71
CHEMBL236564 IC50 = 1947.0 nM 5.71
CHEMBL3797790 IC50 = 1997.0 nM 5.70
CHEMBL3814229 IC50 = 2731.0 nM 5.56
CHEMBL3798328 IC50 = 3035.0 nM 5.52
CHEMBL3800015 IC50 = 3297.0 nM 5.48
CHEMBL3798718 IC50 = 3322.0 nM 5.48
CHEMBL3800571 IC50 = 3384.0 nM 5.47
CHEMBL3798376 IC50 = 3570.0 nM 5.45
CHEMBL3798852 IC50 = 4312.0 nM 5.37
CHEMBL3797620 IC50 = 4701.0 nM 5.33
CHEMBL3814528 IC50 = 5491.0 nM 5.26
CHEMBL3797456 IC50 = 6037.0 nM 5.22
CHEMBL235938 IC50 = 6422.0 nM 5.19
CHEMBL338227 IC50 = 7860.0 nM 5.11
CHEMBL3797682 IC50 = 9980.0 nM 5.00
CHEMBL397524 IC50 - -