Assay Detail
Binding
CHEMBL3819947
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of of human TREK1 expressed in HEK293 cells assessed as reversible current depression
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Potassium channel subfamily K member 2 (CHEMBL2321615) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 5.40 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL28854 | SIPATRIGINE | 2.0 | 1 | 5.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL28854 | SIPATRIGINE | IC50 | = | 4000.0 | nM | 5.40 |