Assay Detail
Binding
CHEMBL3819974
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Inhibition of human placental microsomal aromatase using [1beta-3H] androstenedione as substrate assessed as tritiated H2O release preincubated for 5 mins followed by protein addition measured after 20 mins by beta counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.45 | 6.78 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3818725 | — | — | 1 | 6.78 |
| CHEMBL3819184 | — | — | 1 | 6.75 |
| CHEMBL3818442 | — | — | 1 | 6.29 |
| CHEMBL3623216 | — | — | 1 | 5.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3818725 | — | IC50 | = | 168.0 | nM | 6.78 |
| CHEMBL3819184 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL3818442 | — | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL3623216 | — | IC50 | = | 1019.8 | nM | 5.99 |