Assay Detail
Binding
CHEMBL3820005
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of fluorescein-labeled Bid BH3 peptide (79 to 99 residues) binding to His-tagged MCL1 (171 to 327 residues) (unknown origin) expressed in Escherichia coli Bl21(DE3) cells incubated for 3 hrs by fluorescence polarization assay
4
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1 (CHEMBL4361) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecules targeting Mcl-1: the search for a silver bullet in cancer therapy
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.77 | 6.77 |
| Ki | 1 | 5.73 | 5.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3265300 | — | — | 1 | 6.77 |
| CHEMBL3265297 | — | — | 1 | 6.77 |
| CHEMBL3265298 | — | — | 1 | 6.77 |
| CHEMBL1331211 | — | — | 1 | 5.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3265300 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3265297 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL3265298 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL1331211 | — | Ki | = | 1870.0 | nM | 5.73 |