Assay Detail
Binding
CHEMBL3820050
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]N-methylspiperone from human recombinant dopamine D4 receptor incubated for 1.5 hrs by microbeta scintillation counting method
31
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 31 | 6.69 | 8.81 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3818478 | — | — | 2 | 8.81 |
| CHEMBL3818805 | — | — | 2 | 7.80 |
| CHEMBL3818799 | — | — | 2 | 7.17 |
| CHEMBL3818935 | — | — | 2 | 6.93 |
| CHEMBL3819567 | — | — | 2 | 6.88 |
| CHEMBL2037432 | — | — | 2 | 6.85 |
| CHEMBL2037526 | — | — | 2 | 6.79 |
| CHEMBL3819642 | — | — | 2 | 6.79 |
| CHEMBL3818940 | — | — | 1 | 6.64 |
| CHEMBL3819434 | — | — | 2 | 6.37 |
| CHEMBL3818881 | — | — | 2 | 6.29 |
| CHEMBL3818398 | — | — | 2 | 6.17 |
| CHEMBL3819153 | — | — | 2 | 6.08 |
| CHEMBL3819403 | — | — | 2 | 5.92 |
| CHEMBL3818124 | — | — | 2 | 5.82 |
| CHEMBL2037520 | — | — | 2 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3818478 | — | Ki | = | 1.549 | nM | 8.81 |
| CHEMBL3818478 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL3818805 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL3818805 | — | Ki | = | 16.22 | nM | 7.79 |
| CHEMBL3818799 | — | Ki | = | 67.61 | nM | 7.17 |
| CHEMBL3818799 | — | Ki | = | 68.0 | nM | 7.17 |
| CHEMBL3818935 | — | Ki | = | 118.0 | nM | 6.93 |
| CHEMBL3818935 | — | Ki | = | 117.49 | nM | 6.93 |
| CHEMBL3819567 | — | Ki | = | 132.0 | nM | 6.88 |
| CHEMBL3819567 | — | Ki | = | 131.83 | nM | 6.88 |
| CHEMBL2037432 | — | Ki | = | 141.25 | nM | 6.85 |
| CHEMBL2037432 | — | Ki | = | 140.0 | nM | 6.85 |
| CHEMBL2037526 | — | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL2037526 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL3819642 | — | Ki | = | 162.18 | nM | 6.79 |
| CHEMBL3819642 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL3818940 | — | Ki | = | 229.0 | nM | 6.64 |
| CHEMBL3819434 | — | Ki | = | 432.0 | nM | 6.37 |
| CHEMBL3819434 | — | Ki | = | 436.52 | nM | 6.36 |
| CHEMBL3818881 | — | Ki | = | 508.0 | nM | 6.29 |
| CHEMBL3818881 | — | Ki | = | 512.86 | nM | 6.29 |
| CHEMBL3818398 | — | Ki | = | 671.0 | nM | 6.17 |
| CHEMBL3818398 | — | Ki | = | 676.08 | nM | 6.17 |
| CHEMBL3819153 | — | Ki | = | 831.76 | nM | 6.08 |
| CHEMBL3819153 | — | Ki | = | 841.0 | nM | 6.08 |
| CHEMBL3819403 | — | Ki | = | 1217.0 | nM | 5.92 |
| CHEMBL3819403 | — | Ki | = | 1230.27 | nM | 5.91 |
| CHEMBL3818124 | — | Ki | = | 1512.0 | nM | 5.82 |
| CHEMBL3818124 | — | Ki | = | 1584.89 | nM | 5.80 |
| CHEMBL2037520 | — | Ki | = | 1698.24 | nM | 5.77 |
| CHEMBL2037520 | — | Ki | = | 1710.0 | nM | 5.77 |