Assay Detail
ADMET
CHEMBL3820064
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]Mesulergine from human recombinant 5HT2C receptor incubated for 1.5 hrs by microbeta scintillation counting method
11
Total Activities
9
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of CNS multi-receptor ligands: Modification of known D2 pharmacophores.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 7 | - | - |
| Ki | 4 | 5.77 | 6.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3818124 | — | — | 2 | 6.21 |
| CHEMBL3819434 | — | — | 2 | 5.34 |
| CHEMBL3819567 | — | — | 1 | - |
| CHEMBL2037526 | — | — | 1 | - |
| CHEMBL3818935 | — | — | 1 | - |
| CHEMBL3818478 | — | — | 1 | - |
| CHEMBL3819153 | — | — | 1 | - |
| CHEMBL3818805 | — | — | 1 | - |
| CHEMBL3818881 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3818124 | — | Ki | = | 614.0 | nM | 6.21 |
| CHEMBL3818124 | — | Ki | = | 616.6 | nM | 6.21 |
| CHEMBL3819434 | — | Ki | = | 4570.88 | nM | 5.34 |
| CHEMBL3819434 | — | Ki | = | 4623.0 | nM | 5.33 |
| CHEMBL3819567 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL2037526 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL3818935 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL3818478 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL3819153 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL3818805 | — | Inhibition | < | 50.0 | % | - |
| CHEMBL3818881 | — | Inhibition | < | 50.0 | % | - |