Assay Detail
Binding
CHEMBL3820409
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Inhibition of bovine recombinant eNOS expressed in Escherichia coli using L-arginine as substrate assessed as reduction in NO production measured for 6 mins in presence of tetrahydrobiopterin by hemoglobin capture assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 4.78 | 4.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3818373 | — | — | 1 | 4.88 |
| CHEMBL3818566 | — | — | 1 | 4.78 |
| CHEMBL3819551 | — | — | 1 | 4.69 |
| CHEMBL3818545 | — | — | 1 | - |
| CHEMBL3819582 | — | — | 1 | - |
| CHEMBL3818649 | — | — | 1 | - |
| CHEMBL3819644 | — | — | 1 | - |
| CHEMBL3818073 | — | — | 1 | - |
| CHEMBL3819046 | — | — | 1 | - |
| CHEMBL3818486 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3818373 | — | Ki | = | 13247.0 | nM | 4.88 |
| CHEMBL3818566 | — | Ki | = | 16637.0 | nM | 4.78 |
| CHEMBL3819551 | — | Ki | = | 20487.0 | nM | 4.69 |
| CHEMBL3818545 | — | Ki | > | 30000.0 | nM | - |
| CHEMBL3819582 | — | Ki | - | — | - | |
| CHEMBL3818649 | — | Ki | - | — | - | |
| CHEMBL3819644 | — | Ki | - | — | - | |
| CHEMBL3818073 | — | Ki | - | — | - | |
| CHEMBL3819046 | — | Ki | - | — | - | |
| CHEMBL3818486 | — | Ki | - | — | - |