Assay Detail
Binding
CHEMBL3820544
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental microsomal aromatase using [1beta-3H] androstenedione as substrate assessed as tritiated H2O release after 15 mins by liquid scintillation counting method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.26 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3819549 | — | — | 1 | 6.35 |
| CHEMBL3623223 | — | — | 1 | 6.33 |
| CHEMBL3818728 | — | — | 1 | 6.23 |
| CHEMBL3818338 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3819549 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL3623223 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL3818728 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL3818338 | — | IC50 | = | 750.0 | nM | 6.12 |