Assay Detail
Binding
CHEMBL3820547
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human placental microsomal aromatase using testosterone as substrate assessed as formation of estradiol after 10 mins
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Recent Progress in the Discovery of Next Generation Inhibitors of Aromatase from the Structure-Function Perspective.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.37 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2386284 | — | — | 1 | 7.52 |
| CHEMBL1093458 | ENDOXIFEN | 3.0 | 1 | 5.22 |
| CHEMBL489 | AFIMOXIFENE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2386284 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL1093458 | ENDOXIFEN | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL489 | AFIMOXIFENE | IC50 | = | 530000.0 | nM | - |