Assay Detail
Binding
CHEMBL3820567
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Inhibition of PI3K (unknown origin) assessed as reduction in lipid kinase activity by fluorescence-based Adapta TR-FRET assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of Bifunctional Oncogenic Target Inhibitors against Allosteric Mitogen-Activated Protein Kinase (MEK1) and Phosphatidylinositol 3-Kinase (PI3K).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.75 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3819622 | — | — | 1 | 7.27 |
| CHEMBL3819302 | — | — | 1 | 6.72 |
| CHEMBL3819520 | — | — | 1 | 6.54 |
| CHEMBL3818677 | — | — | 1 | 6.47 |
| CHEMBL507361 | MIRDAMETINIB | 2.0 | 1 | - |
| CHEMBL244488 | — | — | 1 | - |
| CHEMBL3818606 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3819622 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3819302 | — | IC50 | = | 191.0 | nM | 6.72 |
| CHEMBL3819520 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL3818677 | — | IC50 | = | 341.0 | nM | 6.47 |
| CHEMBL507361 | MIRDAMETINIB | IC50 | - | — | - | |
| CHEMBL244488 | — | IC50 | - | — | - | |
| CHEMBL3818606 | — | IC50 | - | — | - |