Assay Detail
Binding
CHEMBL3821236
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.75 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3818537 | — | — | 1 | 7.64 |
| CHEMBL3818149 | — | — | 1 | 7.57 |
| CHEMBL3818107 | — | — | 1 | 7.57 |
| CHEMBL3819103 | — | — | 1 | 7.40 |
| CHEMBL3819337 | — | — | 1 | 7.19 |
| CHEMBL3817950 | — | — | 1 | 7.12 |
| CHEMBL3818875 | GSK2256294 | 2.0 | 1 | 6.96 |
| CHEMBL1231797 | — | — | 1 | 6.85 |
| CHEMBL3818683 | — | — | 1 | 6.52 |
| CHEMBL3818601 | — | — | 1 | 6.24 |
| CHEMBL3818059 | — | — | 1 | 6.07 |
| CHEMBL3818976 | — | — | 1 | 5.92 |
| CHEMBL3818218 | — | — | 1 | 5.89 |
| CHEMBL3819535 | — | — | 1 | 5.60 |
| CHEMBL3318038 | — | — | 1 | - |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3818537 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3818149 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3818107 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3819103 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL3819337 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3817950 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL3818875 | GSK2256294 | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL1231797 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL3818683 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3818601 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL3818059 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL3818976 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3818218 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL3819535 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3318038 | — | IC50 | - | — | - | |
| CHEMBL264374 | BEZAFIBRATE | IC50 | - | — | - |