Assay Detail
Binding
CHEMBL3821237
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Gal4-tagged human PPARalpha ligand binding domain expressed in COS-7 cells measured after overnight incubation by dual-glo luciferase reporter gene assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL239) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and synthesis of fused soluble epoxide hydrolase/peroxisome proliferator-activated receptor modulators
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 5.97 | 7.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3318038 | — | — | 1 | 7.17 |
| CHEMBL3818976 | — | — | 1 | 5.60 |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | 5.15 |
| CHEMBL3819535 | — | — | 1 | - |
| CHEMBL3818218 | — | — | 1 | - |
| CHEMBL3818149 | — | — | 1 | - |
| CHEMBL3817950 | — | — | 1 | - |
| CHEMBL3818537 | — | — | 1 | - |
| CHEMBL3819103 | — | — | 1 | - |
| CHEMBL3818875 | GSK2256294 | 2.0 | 1 | - |
| CHEMBL1231797 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3318038 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL3818976 | — | EC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL264374 | BEZAFIBRATE | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3819535 | — | EC50 | - | — | - | |
| CHEMBL3818218 | — | EC50 | - | — | - | |
| CHEMBL3818149 | — | EC50 | - | — | - | |
| CHEMBL3817950 | — | EC50 | - | — | - | |
| CHEMBL3818537 | — | EC50 | - | — | - | |
| CHEMBL3819103 | — | EC50 | - | — | - | |
| CHEMBL3818875 | GSK2256294 | EC50 | - | — | - | |
| CHEMBL1231797 | — | EC50 | - | — | - |