Assay Detail
Functional
CHEMBL3821590
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Antiviral activity against Influenza A virus (A/Aichi/75/2008(H3N2)) infected in dog AX4 cells preincubated for 1 hr followed by infection measured after 19 to 20 hrs by galactosidase-based fluorescence assay and peroxidase-based chromogenic assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Influenza A virus (A/Aichi/75/2008(H3N2)) |
| Cell Type | AX4 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.90 | 10.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3818159 | — | — | 1 | 10.15 |
| CHEMBL222813 | ZANAMIVIR | 4.0 | 1 | 8.97 |
| CHEMBL3818654 | — | — | 1 | 8.87 |
| CHEMBL3819510 | — | — | 1 | 7.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3818159 | — | IC50 | = | 0.07 | nM | 10.15 |
| CHEMBL222813 | ZANAMIVIR | IC50 | = | 1.07 | nM | 8.97 |
| CHEMBL3818654 | — | IC50 | = | 1.34 | nM | 8.87 |
| CHEMBL3819510 | — | IC50 | = | 24.7 | nM | 7.61 |