Assay Detail
Binding
CHEMBL3821983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Competitive inhibition of wild type beta-catenin (unknown origin) expressed in Escherichia coli BL21 DE3 interaction with N-terminally biotinylated human BCL9 (350 to 375 residues) by alpha screen assay
24
Total Activities
23
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
beta-catenin-B-cell lymphoma 9 protein complex (CHEMBL3885525) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Structure-Based Design of 1,4-Dibenzoylpiperazines as β-Catenin/B-Cell Lymphoma 9 Protein-Protein Interaction Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 23 | 4.53 | 5.68 |
| IC50 | 1 | 5.25 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3819630 | — | — | 1 | 5.68 |
| CHEMBL3819506 | — | — | 2 | 5.28 |
| CHEMBL484853 | CARNOSIC ACID | — | 1 | 5.28 |
| CHEMBL3819020 | — | — | 1 | 4.80 |
| CHEMBL3818707 | — | — | 1 | 4.72 |
| CHEMBL3819288 | — | — | 1 | 4.70 |
| CHEMBL3819165 | — | — | 1 | 4.60 |
| CHEMBL3818097 | — | — | 1 | 4.46 |
| CHEMBL3819088 | — | — | 1 | 4.43 |
| CHEMBL3818263 | — | — | 1 | 4.35 |
| CHEMBL3819332 | — | — | 1 | 4.32 |
| CHEMBL3818667 | — | — | 1 | 4.28 |
| CHEMBL3818058 | — | — | 1 | 4.26 |
| CHEMBL3819368 | — | — | 1 | 4.24 |
| CHEMBL3818956 | — | — | 1 | 4.17 |
| CHEMBL3818207 | — | — | 1 | 4.16 |
| CHEMBL3818280 | — | — | 1 | 4.16 |
| CHEMBL3817935 | — | — | 1 | 4.12 |
| CHEMBL3818949 | — | — | 1 | 4.09 |
| CHEMBL3818029 | — | — | 1 | - |
| CHEMBL3819443 | — | — | 1 | - |
| CHEMBL3818748 | — | — | 1 | - |
| CHEMBL3818840 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3819630 | — | Ki | = | 2100.0 | nM | 5.68 |
| CHEMBL3819506 | — | Ki | = | 5200.0 | nM | 5.28 |
| CHEMBL484853 | CARNOSIC ACID | Ki | = | 5300.0 | nM | 5.28 |
| CHEMBL3819506 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3819020 | — | Ki | = | 16000.0 | nM | 4.80 |
| CHEMBL3818707 | — | Ki | = | 19000.0 | nM | 4.72 |
| CHEMBL3819288 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL3819165 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL3818097 | — | Ki | = | 35000.0 | nM | 4.46 |
| CHEMBL3819088 | — | Ki | = | 37000.0 | nM | 4.43 |
| CHEMBL3818263 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL3819332 | — | Ki | = | 48000.0 | nM | 4.32 |
| CHEMBL3818667 | — | Ki | = | 53000.0 | nM | 4.28 |
| CHEMBL3818058 | — | Ki | = | 55000.0 | nM | 4.26 |
| CHEMBL3819368 | — | Ki | = | 57000.0 | nM | 4.24 |
| CHEMBL3818956 | — | Ki | = | 67000.0 | nM | 4.17 |
| CHEMBL3818207 | — | Ki | = | 70000.0 | nM | 4.16 |
| CHEMBL3818280 | — | Ki | = | 69000.0 | nM | 4.16 |
| CHEMBL3817935 | — | Ki | = | 76000.0 | nM | 4.12 |
| CHEMBL3818949 | — | Ki | = | 82000.0 | nM | 4.09 |
| CHEMBL3818029 | — | Ki | = | 490000.0 | nM | - |
| CHEMBL3819443 | — | Ki | = | 170000.0 | nM | - |
| CHEMBL3818748 | — | Ki | > | 500000.0 | nM | - |
| CHEMBL3818840 | — | Ki | = | 130000.0 | nM | - |