Assay Detail
Functional
CHEMBL3824534
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-231 cells assessed as reduction in cell viability after 5 days by PrestoBlue assay
29
Total Activities
29
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 5.67 | 8.05 |
| Activity | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3824089 | — | — | 1 | 8.05 |
| CHEMBL3824116 | — | — | 1 | 7.51 |
| CHEMBL3824233 | — | — | 1 | 7.41 |
| CHEMBL3823620 | — | — | 1 | 7.14 |
| CHEMBL3823104 | — | — | 1 | 7.09 |
| CHEMBL3823543 | — | — | 1 | 6.78 |
| CHEMBL3824279 | — | — | 1 | 5.71 |
| CHEMBL3823506 | — | — | 1 | 5.70 |
| CHEMBL3823451 | — | — | 1 | 5.56 |
| CHEMBL3824228 | — | — | 1 | 5.45 |
| CHEMBL3823845 | — | — | 1 | 5.38 |
| CHEMBL3823948 | — | — | 1 | 5.38 |
| CHEMBL3822874 | — | — | 1 | 5.17 |
| CHEMBL3822579 | — | — | 1 | 5.01 |
| CHEMBL3823239 | — | — | 1 | 4.91 |
| CHEMBL3823255 | — | — | 1 | 4.87 |
| CHEMBL3823711 | — | — | 1 | 4.82 |
| CHEMBL3823108 | — | — | 1 | 4.75 |
| CHEMBL3822469 | — | — | 1 | 4.57 |
| CHEMBL3822652 | — | — | 1 | 4.54 |
| CHEMBL3823660 | — | — | 1 | 4.49 |
| CHEMBL3823135 | — | — | 1 | 4.40 |
| CHEMBL3823861 | — | — | 1 | - |
| CHEMBL3824021 | — | — | 1 | - |
| CHEMBL3824156 | — | — | 1 | - |
| CHEMBL3823344 | — | — | 1 | - |
| CHEMBL1241481 | — | — | 1 | - |
| CHEMBL5416410 | DASATINIB | 4.0 | 1 | - |
| CHEMBL3823556 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3824089 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3824116 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3824233 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL3823620 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL3823104 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL3823543 | — | EC50 | = | 167.0 | nM | 6.78 |
| CHEMBL3824279 | — | EC50 | = | 1960.0 | nM | 5.71 |
| CHEMBL3823506 | — | EC50 | = | 1990.0 | nM | 5.70 |
| CHEMBL3823451 | — | EC50 | = | 2760.0 | nM | 5.56 |
| CHEMBL3824228 | — | EC50 | = | 3570.0 | nM | 5.45 |
| CHEMBL3823845 | — | EC50 | = | 4140.0 | nM | 5.38 |
| CHEMBL3823948 | — | EC50 | = | 4150.0 | nM | 5.38 |
| CHEMBL3822874 | — | EC50 | = | 6720.0 | nM | 5.17 |
| CHEMBL3822579 | — | EC50 | = | 9710.0 | nM | 5.01 |
| CHEMBL3823239 | — | EC50 | = | 12180.0 | nM | 4.91 |
| CHEMBL3823255 | — | EC50 | = | 13590.0 | nM | 4.87 |
| CHEMBL3823711 | — | EC50 | = | 15230.0 | nM | 4.82 |
| CHEMBL3823108 | — | EC50 | = | 17740.0 | nM | 4.75 |
| CHEMBL3822469 | — | EC50 | = | 26770.0 | nM | 4.57 |
| CHEMBL3822652 | — | EC50 | = | 28590.0 | nM | 4.54 |
| CHEMBL3823660 | — | EC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL3823135 | — | EC50 | = | 40200.0 | nM | 4.40 |
| CHEMBL3823861 | — | Activity | - | — | - | |
| CHEMBL3824021 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3824156 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL3823344 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL1241481 | — | Activity | - | — | - | |
| CHEMBL5416410 | DASATINIB | Activity | - | — | - | |
| CHEMBL3823556 | — | Activity | - | — | - |