Assay Detail
Functional
CHEMBL3824992
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Antiproliferation activity against human MDA-MB-231 cells assessed as reduction in cell viability after 72 hrs by WST-8 assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
New sesquiterpene lactones, vernonilides A and B, from the seeds of Vernonia anthelmintica in Uyghur and their antiproliferative activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.87 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3823729 | — | — | 1 | 6.60 |
| CHEMBL251225 | VERNODALIN | — | 1 | 6.52 |
| CHEMBL3822467 | — | — | 1 | 6.46 |
| CHEMBL3823923 | — | — | 1 | 5.87 |
| CHEMBL290210 | VERNOLEPIN | — | 1 | 5.72 |
| CHEMBL3823910 | — | — | 1 | 5.50 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.28 |
| CHEMBL3824194 | — | — | 1 | 5.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3823729 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL251225 | VERNODALIN | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL3822467 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL3823923 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL290210 | VERNOLEPIN | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL3823910 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3824194 | — | IC50 | = | 9500.0 | nM | 5.02 |