Assay Detail
Binding
CHEMBL3824993
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-resiniferatoxin from human TRPV1 expressed in CHO cells incubated for 60 mins by scintillation counting analysis
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of N-(3-fluoro-4-methylsulfonamidomethylphenyl)urea as a potent TRPV1 antagonistic template.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 7.15 | 8.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2177429 | — | — | 1 | 8.53 |
| CHEMBL3694601 | — | — | 1 | 8.17 |
| CHEMBL2177428 | — | — | 1 | 8.10 |
| CHEMBL3822842 | — | — | 1 | 7.50 |
| CHEMBL3823425 | — | — | 1 | 7.27 |
| CHEMBL3822908 | — | — | 1 | 7.23 |
| CHEMBL3824160 | — | — | 1 | 7.08 |
| CHEMBL3823983 | — | — | 1 | 6.68 |
| CHEMBL3822749 | — | — | 1 | 6.64 |
| CHEMBL3823968 | — | — | 1 | 6.39 |
| CHEMBL3822592 | — | — | 1 | 6.31 |
| CHEMBL3822772 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2177429 | — | Ki | = | 2.95 | nM | 8.53 |
| CHEMBL3694601 | — | Ki | = | 6.77 | nM | 8.17 |
| CHEMBL2177428 | — | Ki | = | 7.9 | nM | 8.10 |
| CHEMBL3822842 | — | Ki | = | 31.6 | nM | 7.50 |
| CHEMBL3823425 | — | Ki | = | 54.0 | nM | 7.27 |
| CHEMBL3822908 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL3824160 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL3823983 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL3822749 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL3823968 | — | Ki | = | 410.0 | nM | 6.39 |
| CHEMBL3822592 | — | Ki | = | 490.0 | nM | 6.31 |
| CHEMBL3822772 | — | Ki | = | 1160.0 | nM | 5.94 |