Assay Detail
Functional
CHEMBL3825517
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiinvasive activity against human MDA-MB-231 cells expressing c-MET assessed as inhibition of HGF-induced cell invasion incubated for 24 hrs by calcien-AM dye based BME cell invasion assay
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel c-Met inhibitory olive secoiridoid semisynthetic analogs for the control of invasive breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.00 | 5.57 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3822800 | — | — | 2 | 5.57 |
| CHEMBL3823193 | — | — | 1 | 5.15 |
| CHEMBL3823189 | — | — | 1 | 4.85 |
| CHEMBL3823110 | — | — | 1 | 4.74 |
| CHEMBL2348314 | TYROSOL SINAPATE | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3822800 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL3823193 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL3823189 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL3823110 | — | IC50 | = | 18200.0 | nM | 4.74 |
| CHEMBL2348314 | TYROSOL SINAPATE | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL3822800 | — | Inhibition | - | % | - |