Assay Detail
Functional
CHEMBL3825519
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Antiproliferative activity against human MDA-MB-231 cells expressing c-MET assessed as inhibition of HGF-induced cell growth incubated for 72 hrs by MTT assay
48
Total Activities
47
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel c-Met inhibitory olive secoiridoid semisynthetic analogs for the control of invasive breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 4.75 | 5.42 |
| GI | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3822800 | — | — | 2 | 5.42 |
| CHEMBL3823193 | — | — | 1 | 5.38 |
| CHEMBL3823189 | — | — | 1 | 5.36 |
| CHEMBL3823617 | — | — | 1 | 5.20 |
| CHEMBL3822598 | — | — | 1 | 5.14 |
| CHEMBL3824063 | — | — | 1 | 5.12 |
| CHEMBL3823798 | — | — | 1 | 5.09 |
| CHEMBL3823377 | — | — | 1 | 5.07 |
| CHEMBL3823395 | — | — | 1 | 5.04 |
| CHEMBL3823804 | — | — | 1 | 5.04 |
| CHEMBL3823418 | — | — | 1 | 5.03 |
| CHEMBL3823321 | — | — | 1 | 5.02 |
| CHEMBL3822690 | — | — | 1 | 5.00 |
| CHEMBL3823881 | — | — | 1 | 5.00 |
| CHEMBL3823650 | — | — | 1 | 4.99 |
| CHEMBL3823866 | — | — | 1 | 4.98 |
| CHEMBL3822697 | — | — | 1 | 4.97 |
| CHEMBL3822508 | — | — | 1 | 4.93 |
| CHEMBL3822893 | — | — | 1 | 4.91 |
| CHEMBL3823553 | — | — | 1 | 4.90 |
| CHEMBL3823086 | — | — | 1 | 4.89 |
| CHEMBL3824070 | — | — | 1 | 4.88 |
| CHEMBL3823701 | — | — | 1 | 4.86 |
| CHEMBL3822560 | — | — | 1 | 4.83 |
| CHEMBL3823110 | — | — | 1 | 4.82 |
| CHEMBL3822722 | — | — | 1 | 4.82 |
| CHEMBL3824255 | — | — | 1 | 4.81 |
| CHEMBL3822574 | — | — | 1 | 4.80 |
| CHEMBL3823987 | — | — | 1 | 4.80 |
| CHEMBL3823265 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3822800 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL3823193 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3823189 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL3823617 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL3822598 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL3824063 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL3823798 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3823377 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL3823804 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3823395 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL3823418 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL3823321 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL3823881 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3822690 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3823650 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL3823866 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL3822697 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL3822508 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL3822893 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL3823553 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL3823086 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL3824070 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL3823701 | — | IC50 | = | 13700.0 | nM | 4.86 |
| CHEMBL3822560 | — | IC50 | = | 14700.0 | nM | 4.83 |
| CHEMBL3823110 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL3822722 | — | IC50 | = | 15100.0 | nM | 4.82 |
| CHEMBL3824255 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL3822574 | — | IC50 | = | 15800.0 | nM | 4.80 |
| CHEMBL3823987 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL3823265 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL3822615 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL3822534 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL3823769 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL3822765 | — | IC50 | = | 25300.0 | nM | 4.60 |
| CHEMBL3822833 | — | IC50 | = | 27900.0 | nM | 4.55 |
| CHEMBL3823470 | — | IC50 | = | 40500.0 | nM | 4.39 |
| CHEMBL3628211 | — | IC50 | = | 59900.0 | nM | 4.22 |
| CHEMBL3823770 | — | IC50 | = | 68800.0 | nM | 4.16 |
| CHEMBL3823074 | — | IC50 | = | 72300.0 | nM | 4.14 |
| CHEMBL226587 | TRANS-N-SINAPOYLTYRAMINE | IC50 | = | 72800.0 | nM | 4.14 |
| CHEMBL2348314 | TYROSOL SINAPATE | IC50 | = | 79500.0 | nM | 4.10 |
| CHEMBL3823683 | — | IC50 | = | 80400.0 | nM | 4.09 |
| CHEMBL3823463 | — | IC50 | = | 83200.0 | nM | 4.08 |
| CHEMBL481245 | — | IC50 | = | 87600.0 | nM | 4.06 |
| CHEMBL3823033 | — | IC50 | = | 89900.0 | nM | 4.05 |
| CHEMBL3823869 | — | IC50 | = | 91300.0 | nM | 4.04 |
| CHEMBL3822800 | — | GI | - | — | - | |
| CHEMBL53566 | TYROSOL | IC50 | > | 100000.0 | nM | - |