Assay Detail
Functional
CHEMBL3825523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antimigratory activity against human MDA-MB-231 cells expressing c-MET assessed as inhibition of HGF-induced cell migration incubated for 24 hrs by Giemsa staining based wound healing assay
48
Total Activities
47
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Novel c-Met inhibitory olive secoiridoid semisynthetic analogs for the control of invasive breast cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 47 | 5.05 | 5.60 |
| Inhibition | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3822800 | — | — | 2 | 5.60 |
| CHEMBL3823418 | — | — | 1 | 5.44 |
| CHEMBL3823321 | — | — | 1 | 5.41 |
| CHEMBL3823193 | — | — | 1 | 5.40 |
| CHEMBL3823189 | — | — | 1 | 5.39 |
| CHEMBL3823650 | — | — | 1 | 5.39 |
| CHEMBL3822615 | — | — | 1 | 5.38 |
| CHEMBL3822574 | — | — | 1 | 5.37 |
| CHEMBL3823553 | — | — | 1 | 5.35 |
| CHEMBL3823866 | — | — | 1 | 5.34 |
| CHEMBL3823395 | — | — | 1 | 5.34 |
| CHEMBL3823033 | — | — | 1 | 5.34 |
| CHEMBL3824063 | — | — | 1 | 5.32 |
| CHEMBL3823377 | — | — | 1 | 5.28 |
| CHEMBL3822598 | — | — | 1 | 5.27 |
| CHEMBL3823617 | — | — | 1 | 5.27 |
| CHEMBL3823881 | — | — | 1 | 5.25 |
| CHEMBL3823798 | — | — | 1 | 5.21 |
| CHEMBL3823110 | — | — | 1 | 5.12 |
| CHEMBL3823086 | — | — | 1 | 5.12 |
| CHEMBL3823804 | — | — | 1 | 5.11 |
| CHEMBL3822508 | — | — | 1 | 5.09 |
| CHEMBL3823701 | — | — | 1 | 5.09 |
| CHEMBL3822690 | — | — | 1 | 5.09 |
| CHEMBL3822697 | — | — | 1 | 5.08 |
| CHEMBL3822534 | — | — | 1 | 5.06 |
| CHEMBL3822722 | — | — | 1 | 5.03 |
| CHEMBL3822893 | — | — | 1 | 4.93 |
| CHEMBL3824070 | — | — | 1 | 4.90 |
| CHEMBL3823987 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3822800 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL3823418 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL3823321 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL3823193 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL3823189 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3823650 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL3822615 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL3822574 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL3823553 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL3823866 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3823395 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3823033 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL3824063 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL3823377 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL3823617 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3822598 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL3823881 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL3823798 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL3823086 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL3823110 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL3823804 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL3823701 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL3822508 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3822690 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL3822697 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL3822534 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL3822722 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL3822893 | — | IC50 | = | 11800.0 | nM | 4.93 |
| CHEMBL3824070 | — | IC50 | = | 12600.0 | nM | 4.90 |
| CHEMBL3823987 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL3822560 | — | IC50 | = | 13300.0 | nM | 4.88 |
| CHEMBL3823683 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL3824255 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL3823074 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL3822833 | — | IC50 | = | 18800.0 | nM | 4.73 |
| CHEMBL3823769 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL3822765 | — | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL3823770 | — | IC50 | = | 30400.0 | nM | 4.52 |
| CHEMBL3628211 | — | IC50 | = | 30500.0 | nM | 4.52 |
| CHEMBL3823470 | — | IC50 | = | 31200.0 | nM | 4.51 |
| CHEMBL2348314 | TYROSOL SINAPATE | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL3823463 | — | IC50 | = | 40600.0 | nM | 4.39 |
| CHEMBL481245 | — | IC50 | = | 44300.0 | nM | 4.35 |
| CHEMBL3823265 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL226587 | TRANS-N-SINAPOYLTYRAMINE | IC50 | > | 50000.0 | nM | - |
| CHEMBL3823869 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL53566 | TYROSOL | IC50 | > | 50000.0 | nM | - |
| CHEMBL3822800 | — | Inhibition | - | % | - |