Assay Detail
Binding
CHEMBL3826032
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDK1 (unknown origin) by FRET-based Z-lyte assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
3-phosphoinositide-dependent protein kinase 1 (CHEMBL2534) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.12 | 6.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3824119 | — | — | 1 | 6.95 |
| CHEMBL3823844 | — | — | 1 | 6.38 |
| CHEMBL3824264 | — | — | 1 | 6.29 |
| CHEMBL3823622 | — | — | 1 | 5.82 |
| CHEMBL3822974 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3824119 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL3823844 | — | IC50 | = | 416.0 | nM | 6.38 |
| CHEMBL3824264 | — | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL3823622 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL3822974 | — | IC50 | = | 6680.0 | nM | 5.17 |