Assay Detail
Binding
CHEMBL3826222
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Inhibition of soybean 15-LOX using arachidonic acid as substrate by enzyme immunoassay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Glycine max |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.20 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3822823 | — | — | 1 | 5.40 |
| CHEMBL3823621 | — | — | 1 | 5.33 |
| CHEMBL3823010 | — | — | 1 | 5.27 |
| CHEMBL1562610 | MECLOFENAMATE SODIUM | 4.0 | 1 | 5.25 |
| CHEMBL3824017 | — | — | 1 | 5.23 |
| CHEMBL3822882 | — | — | 1 | 5.20 |
| CHEMBL3824335 | — | — | 1 | 5.13 |
| CHEMBL1537950 | — | — | 1 | 5.13 |
| CHEMBL3822637 | — | — | 1 | 5.12 |
| CHEMBL3822602 | — | — | 1 | 5.07 |
| CHEMBL3822900 | — | — | 1 | 5.06 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | - |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3822823 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL3823621 | — | IC50 | = | 4710.0 | nM | 5.33 |
| CHEMBL3823010 | — | IC50 | = | 5410.0 | nM | 5.27 |
| CHEMBL1562610 | MECLOFENAMATE SODIUM | IC50 | = | 5640.0 | nM | 5.25 |
| CHEMBL3824017 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL3822882 | — | IC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL3824335 | — | IC50 | = | 7490.0 | nM | 5.13 |
| CHEMBL1537950 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL3822637 | — | IC50 | = | 7680.0 | nM | 5.12 |
| CHEMBL3822602 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL3822900 | — | IC50 | = | 8680.0 | nM | 5.06 |
| CHEMBL118 | CELECOXIB | IC50 | - | — | - | |
| CHEMBL25 | ASPIRIN | IC50 | - | — | - |