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Assay Detail

CHEMBL3826735

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Functional
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 5 days by PrestoBlue assay
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Autocuration

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.
Fraser C, Dawson JC, Dowling R, Houston DR, Weiss JT, Munro AF, Muir M, Harrington L, Webster SP, Frame MC, Brunton VG, Patton EE, Carragher NO, Unciti-Broceta A.
J Med Chem (2016) 59 : 4697 -4710
PubMed 27115835 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 19 4.84 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3799221 1 6.10
CHEMBL3823861 1 5.72
CHEMBL3822885 1 5.30
CHEMBL3822881 1 5.21
CHEMBL306380 1 5.17
CHEMBL3823797 1 5.12
CHEMBL3823849 1 4.91
CHEMBL3822591 1 4.91
CHEMBL3822571 1 4.87
CHEMBL3823692 1 4.75
CHEMBL3822623 1 4.74
CHEMBL3823991 1 4.52
CHEMBL3823519 1 4.51
CHEMBL3823946 1 4.37
CHEMBL3823606 1 4.31
CHEMBL3823212 1 4.29
CHEMBL3823285 1 4.24
CHEMBL3822743 1 4.03
CHEMBL3822793 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3799221 EC50 = 800.0 nM 6.10
CHEMBL3823861 EC50 = 1900.0 nM 5.72
CHEMBL3822885 EC50 = 5000.0 nM 5.30
CHEMBL3822881 EC50 = 6100.0 nM 5.21
CHEMBL306380 EC50 = 6760.0 nM 5.17
CHEMBL3823797 EC50 = 7600.0 nM 5.12
CHEMBL3823849 EC50 = 12360.0 nM 4.91
CHEMBL3822591 EC50 = 12440.0 nM 4.91
CHEMBL3822571 EC50 = 13500.0 nM 4.87
CHEMBL3823692 EC50 = 17930.0 nM 4.75
CHEMBL3822623 EC50 = 18300.0 nM 4.74
CHEMBL3823991 EC50 = 30300.0 nM 4.52
CHEMBL3823519 EC50 = 30900.0 nM 4.51
CHEMBL3823946 EC50 = 43100.0 nM 4.37
CHEMBL3823606 EC50 = 48780.0 nM 4.31
CHEMBL3823212 EC50 = 51470.0 nM 4.29
CHEMBL3823285 EC50 = 57100.0 nM 4.24
CHEMBL3822743 EC50 = 93600.0 nM 4.03
CHEMBL3822793 EC50 = 263000.0 nM -