Assay Detail
Binding
CHEMBL3828995
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Binding affinity to gag polyprotein in wild type HIV1 NLRepRlucP373S infected in human MT2 cells assessed as inhibition of viral maturation after 4 to 5 days in presence of 10% fetal bovine serum/40% human serum by dual-luciferase reporter assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | MT2 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 7.31 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3827026 | — | — | 1 | 8.24 |
| CHEMBL3827839 | — | — | 1 | 8.06 |
| CHEMBL3787468 | — | — | 1 | 7.37 |
| CHEMBL3775172 | — | — | 1 | 6.98 |
| CHEMBL404519 | BEVIRIMAT | 2.0 | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3827026 | — | EC50 | = | 5.7 | nM | 8.24 |
| CHEMBL3827839 | — | EC50 | = | 8.7 | nM | 8.06 |
| CHEMBL3787468 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL3775172 | — | EC50 | = | 105.0 | nM | 6.98 |
| CHEMBL404519 | BEVIRIMAT | EC50 | = | 1291.0 | nM | 5.89 |