Assay Detail
Functional
CHEMBL3829029
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Cytotoxicity against human MV4-11 cells assessed as growth inhibition after 24 hrs by MTT assay
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MV4-11 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 8.18 | 9.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3827814 | — | — | 1 | 9.82 |
| CHEMBL3827517 | — | — | 1 | 9.72 |
| CHEMBL3622533 | FIMEPINOSTAT | 2.0 | 1 | 9.37 |
| CHEMBL3827281 | — | — | 1 | 9.16 |
| CHEMBL3827296 | — | — | 1 | 9.05 |
| CHEMBL3827794 | — | — | 1 | 9.02 |
| CHEMBL3827865 | — | — | 1 | 8.98 |
| CHEMBL3828636 | — | — | 1 | 8.94 |
| CHEMBL3826997 | — | — | 1 | 8.60 |
| CHEMBL3828289 | — | — | 1 | 8.57 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 8.53 |
| CHEMBL3827650 | — | — | 1 | 8.48 |
| CHEMBL3828486 | — | — | 1 | 8.44 |
| CHEMBL3827660 | — | — | 1 | 8.40 |
| CHEMBL3828180 | — | — | 1 | 8.39 |
| CHEMBL3828518 | — | — | 1 | 8.32 |
| CHEMBL3827612 | — | — | 1 | 8.31 |
| CHEMBL3828628 | — | — | 1 | 8.13 |
| CHEMBL3828492 | — | — | 1 | 8.12 |
| CHEMBL3827894 | — | — | 1 | 8.12 |
| CHEMBL3827317 | — | — | 1 | 8.05 |
| CHEMBL3828482 | — | — | 1 | 7.83 |
| CHEMBL3827780 | — | — | 1 | 7.51 |
| CHEMBL3827489 | — | — | 1 | 7.45 |
| CHEMBL3828747 | — | — | 1 | 7.43 |
| CHEMBL3827398 | — | — | 1 | 7.35 |
| CHEMBL3827004 | — | — | 1 | 7.22 |
| CHEMBL3827056 | — | — | 1 | 7.19 |
| CHEMBL3827738 | — | — | 1 | 7.10 |
| CHEMBL3828408 | — | — | 1 | 6.83 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3827814 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL3827517 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL3622533 | FIMEPINOSTAT | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL3827281 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL3827296 | — | IC50 | = | 0.89 | nM | 9.05 |
| CHEMBL3827794 | — | IC50 | = | 0.95 | nM | 9.02 |
| CHEMBL3827865 | — | IC50 | = | 1.04 | nM | 8.98 |
| CHEMBL3828636 | — | IC50 | = | 1.15 | nM | 8.94 |
| CHEMBL3826997 | — | IC50 | = | 2.51 | nM | 8.60 |
| CHEMBL3828289 | — | IC50 | = | 2.69 | nM | 8.57 |
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 2.97 | nM | 8.53 |
| CHEMBL3827650 | — | IC50 | = | 3.32 | nM | 8.48 |
| CHEMBL3828486 | — | IC50 | = | 3.67 | nM | 8.44 |
| CHEMBL3827660 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3828180 | — | IC50 | = | 4.09 | nM | 8.39 |
| CHEMBL3828518 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL3827612 | — | IC50 | = | 4.85 | nM | 8.31 |
| CHEMBL3828628 | — | IC50 | = | 7.46 | nM | 8.13 |
| CHEMBL3828492 | — | IC50 | = | 7.65 | nM | 8.12 |
| CHEMBL3827894 | — | IC50 | = | 7.65 | nM | 8.12 |
| CHEMBL3827317 | — | IC50 | = | 8.85 | nM | 8.05 |
| CHEMBL3828482 | — | IC50 | = | 14.63 | nM | 7.83 |
| CHEMBL3827780 | — | IC50 | = | 30.8 | nM | 7.51 |
| CHEMBL3827489 | — | IC50 | = | 35.3 | nM | 7.45 |
| CHEMBL3828747 | — | IC50 | = | 37.39 | nM | 7.43 |
| CHEMBL3827398 | — | IC50 | = | 44.77 | nM | 7.35 |
| CHEMBL3827004 | — | IC50 | = | 59.8 | nM | 7.22 |
| CHEMBL3827056 | — | IC50 | = | 65.04 | nM | 7.19 |
| CHEMBL3827738 | — | IC50 | = | 78.82 | nM | 7.10 |
| CHEMBL3828408 | — | IC50 | = | 148.0 | nM | 6.83 |
| CHEMBL3828070 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 230.0 | nM | 6.64 |