Assay Detail
Binding
CHEMBL3829045
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged full length recombinant human p110gamma expressed in baculovirus expression system incubated for 1 hr by ADP-gloreagen assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (CHEMBL3267) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.06 | 8.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3827894 | — | — | 1 | 8.09 |
| CHEMBL3827281 | — | — | 1 | 6.59 |
| CHEMBL3622533 | FIMEPINOSTAT | 2.0 | 1 | 6.51 |
| CHEMBL3828518 | — | — | 1 | - |
| CHEMBL3827814 | — | — | 1 | - |
| CHEMBL3827517 | — | — | 1 | - |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3827894 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL3827281 | — | IC50 | = | 255.0 | nM | 6.59 |
| CHEMBL3622533 | FIMEPINOSTAT | IC50 | = | 311.0 | nM | 6.51 |
| CHEMBL3828518 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3827814 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL3827517 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL483254 | PANOBINOSTAT | IC50 | > | 10000.0 | nM | - |