Assay Detail
Binding
CHEMBL3829047
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC in human HeLa cell nuclear extract using Ac-Leu-Gly-Lys (Ac)-AMC as substrate after 30 mins by fluorescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.38 | 9.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 9.08 |
| CHEMBL3827814 | — | — | 1 | 8.49 |
| CHEMBL3827894 | — | — | 1 | 8.48 |
| CHEMBL3828518 | — | — | 1 | 8.47 |
| CHEMBL3827281 | — | — | 1 | 8.21 |
| CHEMBL3827517 | — | — | 1 | 8.20 |
| CHEMBL3622533 | FIMEPINOSTAT | 2.0 | 1 | 8.17 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL483254 | PANOBINOSTAT | IC50 | = | 0.83 | nM | 9.08 |
| CHEMBL3827814 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3827894 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL3828518 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3827281 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3827517 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3622533 | FIMEPINOSTAT | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 11.5 | nM | 7.94 |