Assay Detail
Binding
CHEMBL3829048
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of HDAC6 in human A2780S cells assessed as tubulin acetylation incubated for 6 hrs by cytoblot assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 6.68 | 6.84 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3827894 | — | — | 1 | 6.84 |
| CHEMBL483254 | PANOBINOSTAT | 4.0 | 1 | 6.82 |
| CHEMBL3827517 | — | — | 1 | 6.73 |
| CHEMBL3827281 | — | — | 1 | 6.70 |
| CHEMBL3827814 | — | — | 1 | 6.68 |
| CHEMBL3622533 | FIMEPINOSTAT | 2.0 | 1 | 6.65 |
| CHEMBL3828518 | — | — | 1 | 6.61 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3827894 | — | EC50 | = | 143.7 | nM | 6.84 |
| CHEMBL483254 | PANOBINOSTAT | EC50 | = | 150.71 | nM | 6.82 |
| CHEMBL3827517 | — | EC50 | = | 187.9 | nM | 6.73 |
| CHEMBL3827281 | — | EC50 | = | 198.6 | nM | 6.70 |
| CHEMBL3827814 | — | EC50 | = | 211.05 | nM | 6.68 |
| CHEMBL3622533 | FIMEPINOSTAT | EC50 | = | 221.75 | nM | 6.65 |
| CHEMBL3828518 | — | EC50 | = | 248.35 | nM | 6.61 |
| CHEMBL98 | VORINOSTAT | EC50 | = | 399.25 | nM | 6.40 |