Assay Detail
Binding
CHEMBL3829316
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Inhibition of recombinant Legionella pneumophila 130b His6-tagged NTPDase (41 to 393 residues) expressed in Escherichia coli BL21(DE3) cells using ADP as substrate incubated for 10 mins by Cheng-Prusoff equation analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Legionella pneumophila 130b |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Inhibitors for the bacterial ectonucleotidase Lp1NTPDase from Legionella pneumophila.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.13 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL597418 | — | — | 1 | 5.52 |
| CHEMBL498423 | — | — | 1 | 5.07 |
| CHEMBL592448 | — | — | 1 | 5.02 |
| CHEMBL271673 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL597418 | — | Ki | = | 2990.0 | nM | 5.52 |
| CHEMBL498423 | — | Ki | = | 8590.0 | nM | 5.07 |
| CHEMBL592448 | — | Ki | = | 9580.0 | nM | 5.02 |
| CHEMBL271673 | — | Ki | = | 12400.0 | nM | 4.91 |