Assay Detail
Binding
CHEMBL3829702
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human CDK19 (1 to 502 residues)/cyclin C (1 to 283 residues) by reporter probe displacement assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-C/Cyclin-dependent kinase 19 (CHEMBL3883323) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.99 | 8.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3828553 | — | — | 1 | 8.25 |
| CHEMBL3827758 | — | — | 1 | 7.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3828553 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3827758 | — | IC50 | = | 18.8 | nM | 7.73 |