Assay Detail
Binding
CHEMBL3829808
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human trypsin using Boc-Gln-Ala-Arg-AMC as substrate after 20 mins by fluorimetric analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Evaluation of bisbenzamidines as inhibitors for matriptase-2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.34 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3594083 | — | — | 1 | 6.72 |
| CHEMBL181480 | — | — | 1 | 6.66 |
| CHEMBL3594082 | — | — | 1 | 6.61 |
| CHEMBL365916 | — | — | 1 | 6.50 |
| CHEMBL9126 | — | — | 1 | 6.29 |
| CHEMBL3828410 | — | — | 1 | 5.85 |
| CHEMBL269032 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3594083 | — | Ki | = | 192.0 | nM | 6.72 |
| CHEMBL181480 | — | Ki | = | 221.0 | nM | 6.66 |
| CHEMBL3594082 | — | Ki | = | 244.0 | nM | 6.61 |
| CHEMBL365916 | — | Ki | = | 316.0 | nM | 6.50 |
| CHEMBL9126 | — | Ki | = | 513.0 | nM | 6.29 |
| CHEMBL3828410 | — | Ki | = | 1420.0 | nM | 5.85 |
| CHEMBL269032 | — | Ki | = | 1900.0 | nM | 5.72 |