Assay Detail
Binding
CHEMBL3829987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ADAM8 (unknown origin) expressed in African green monkey COS7 cells co-expressing CD23 assessed as inhibition of CD23 shedding after 6 hrs by ELISA
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | COS-7 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Disintegrin and metalloproteinase domain-containing protein 8 (CHEMBL5665) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of analogues of the potent ADAM8 inhibitor cyclo(RLsKDK) for the treatment of inflammatory diseases and cancer metastasis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.37 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3828456 | — | — | 1 | 6.85 |
| CHEMBL3828497 | — | — | 1 | 6.80 |
| CHEMBL3827732 | — | — | 1 | 6.72 |
| CHEMBL3827980 | — | — | 1 | 6.66 |
| CHEMBL3827893 | — | — | 1 | 6.62 |
| CHEMBL3827446 | — | — | 1 | 6.59 |
| CHEMBL3827091 | — | — | 1 | 6.43 |
| CHEMBL3827647 | — | — | 1 | 6.42 |
| CHEMBL3828432 | — | — | 1 | 6.38 |
| CHEMBL3827027 | — | — | 1 | 6.34 |
| CHEMBL3827271 | — | — | 1 | 6.05 |
| CHEMBL3828603 | — | — | 1 | 5.91 |
| CHEMBL3827625 | — | — | 1 | 5.78 |
| CHEMBL3827487 | — | — | 1 | 5.63 |
| CHEMBL3827100 | — | — | 1 | - |
| CHEMBL3828319 | — | — | 1 | - |
| CHEMBL3827131 | — | — | 1 | - |
| CHEMBL3828248 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3828456 | — | IC50 | = | 142.0 | nM | 6.85 |
| CHEMBL3828497 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL3827732 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL3827980 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL3827893 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL3827446 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL3827091 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL3827647 | — | IC50 | = | 378.0 | nM | 6.42 |
| CHEMBL3828432 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3827027 | — | IC50 | = | 452.0 | nM | 6.34 |
| CHEMBL3827271 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL3828603 | — | IC50 | = | 1245.0 | nM | 5.91 |
| CHEMBL3827625 | — | IC50 | = | 1645.0 | nM | 5.78 |
| CHEMBL3827487 | — | IC50 | = | 2345.0 | nM | 5.63 |
| CHEMBL3827100 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3828319 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3827131 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL3828248 | — | IC50 | > | 10000.0 | nM | - |