Assay Detail
ADMET
CHEMBL3830047
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human VEGFR2 using poly (Glu, Tyr) 4:1 as substrate after 60 mins by ELISA
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of 3-(5'-Substituted)-Benzimidazole-5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazoles as Potent Fibroblast Growth Factor Receptor Inhibitors: Design, Synthesis, and Biological Evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.05 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3828439 | — | — | 1 | 8.60 |
| CHEMBL3828009 | LY-2874455 | 1.0 | 1 | 8.24 |
| CHEMBL3827178 | — | — | 1 | 8.12 |
| CHEMBL3827268 | — | — | 1 | 8.11 |
| CHEMBL3828740 | — | — | 1 | 8.10 |
| CHEMBL3828122 | — | — | 1 | 8.05 |
| CHEMBL3827180 | — | — | 1 | 7.90 |
| CHEMBL212054 | — | — | 1 | 7.79 |
| CHEMBL3348846 | FEXAGRATINIB | 2.0 | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3828439 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL3828009 | LY-2874455 | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL3827178 | — | IC50 | = | 7.5 | nM | 8.12 |
| CHEMBL3827268 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL3828740 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3828122 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3827180 | — | IC50 | = | 12.6 | nM | 7.90 |
| CHEMBL212054 | — | IC50 | = | 16.4 | nM | 7.79 |
| CHEMBL3348846 | FEXAGRATINIB | IC50 | = | 27.0 | nM | 7.57 |