Assay Detail
Binding
CHEMBL3830258
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Displacement of [3H]di-o-tolylgluanidine from sigma 2 receptor in rat liver membranes after 2 hrs by scintillation counting
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Cavia porcellus |
| Tissue | Liver |
| Subcellular | Membrane |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Oxa-Pictet-Spengler reaction as key step in the synthesis of novel σ receptor ligands with 2-benzopyran structure.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.83 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3827079 | — | — | 1 | 7.70 |
| CHEMBL282433 | DITOLYLGUANIDINE | — | 1 | 7.70 |
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 7.11 |
| CHEMBL3828752 | — | — | 1 | 6.97 |
| CHEMBL3827403 | — | — | 1 | 6.63 |
| CHEMBL3828326 | — | — | 1 | 6.21 |
| CHEMBL3827149 | — | — | 1 | 6.21 |
| CHEMBL3827274 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3827079 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL282433 | DITOLYLGUANIDINE | Ki | = | 20.2 | nM | 7.70 |
| CHEMBL54 | HALOPERIDOL | Ki | = | 78.1 | nM | 7.11 |
| CHEMBL3828752 | — | Ki | = | 107.0 | nM | 6.97 |
| CHEMBL3827403 | — | Ki | = | 234.0 | nM | 6.63 |
| CHEMBL3828326 | — | Ki | = | 617.0 | nM | 6.21 |
| CHEMBL3827149 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL3827274 | — | Ki | = | 785.0 | nM | 6.11 |