Assay Detail
Functional
CHEMBL3830265
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Cytotoxicity against human HepG2 cells assessed as growth inhibition after 72 hrs by MTT assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HepG2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of Oblongifolin C derivatives as c-Met inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.09 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3828522 | — | — | 1 | 5.46 |
| CHEMBL601719 | CRIZOTINIB | 4.0 | 1 | 5.43 |
| CHEMBL443681 | OBLONGIFOLIN C | — | 1 | 4.89 |
| CHEMBL3827230 | — | — | 1 | 4.84 |
| CHEMBL3828445 | — | — | 1 | 4.84 |
| CHEMBL3827525 | — | — | 1 | - |
| CHEMBL3828170 | — | — | 1 | - |
| CHEMBL3827656 | — | — | 1 | - |
| CHEMBL3827777 | — | — | 1 | - |
| CHEMBL3828090 | — | — | 1 | - |
| CHEMBL3828375 | — | — | 1 | - |
| CHEMBL3828225 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3828522 | — | IC50 | = | 3470.0 | nM | 5.46 |
| CHEMBL601719 | CRIZOTINIB | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL443681 | OBLONGIFOLIN C | IC50 | = | 12960.0 | nM | 4.89 |
| CHEMBL3827230 | — | IC50 | = | 14560.0 | nM | 4.84 |
| CHEMBL3828445 | — | IC50 | = | 14350.0 | nM | 4.84 |
| CHEMBL3827525 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3828170 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3827656 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3827777 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3828090 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3828375 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3828225 | — | IC50 | > | 20000.0 | nM | - |