Assay Detail
Functional
CHEMBL3830271
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human HT-29 cells assessed as growth inhibition after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of Oblongifolin C derivatives as c-Met inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.92 | 5.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443681 | OBLONGIFOLIN C | — | 1 | 5.17 |
| CHEMBL3828522 | — | — | 1 | 5.04 |
| CHEMBL3827525 | — | — | 1 | 4.99 |
| CHEMBL3828170 | — | — | 1 | 4.91 |
| CHEMBL3828375 | — | — | 1 | 4.79 |
| CHEMBL3828445 | — | — | 1 | 4.77 |
| CHEMBL3827230 | — | — | 1 | 4.74 |
| CHEMBL3827656 | — | — | 1 | - |
| CHEMBL3827777 | — | — | 1 | - |
| CHEMBL3828090 | — | — | 1 | - |
| CHEMBL3828225 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443681 | OBLONGIFOLIN C | IC50 | = | 6740.0 | nM | 5.17 |
| CHEMBL3828522 | — | IC50 | = | 9220.0 | nM | 5.04 |
| CHEMBL3827525 | — | IC50 | = | 10210.0 | nM | 4.99 |
| CHEMBL3828170 | — | IC50 | = | 12220.0 | nM | 4.91 |
| CHEMBL3828375 | — | IC50 | = | 16330.0 | nM | 4.79 |
| CHEMBL3828445 | — | IC50 | = | 16860.0 | nM | 4.77 |
| CHEMBL3827230 | — | IC50 | = | 18160.0 | nM | 4.74 |
| CHEMBL3827656 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3827777 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3828090 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL3828225 | — | IC50 | > | 20000.0 | nM | - |