Assay Detail
Binding
CHEMBL3830508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I-Sar1-Ile8]Ang2 from human AT1 receptor expressed in HEK293 cell membrane incubated for 1 hr by gamma counting method
10
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploring new scaffolds for angiotensin II receptor antagonism.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.47 | 8.49 |
| Inhibition | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191 | LOSARTAN | 4.0 | 1 | 8.49 |
| CHEMBL1332729 | — | — | 3 | 6.70 |
| CHEMBL1374011 | — | — | 2 | 5.68 |
| CHEMBL1474431 | — | — | 2 | 5.66 |
| CHEMBL1716544 | — | — | 2 | 5.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191 | LOSARTAN | IC50 | = | 3.236 | nM | 8.49 |
| CHEMBL1332729 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL1332729 | — | IC50 | = | 199.0 | nM | 6.70 |
| CHEMBL1374011 | — | IC50 | = | 2089.3 | nM | 5.68 |
| CHEMBL1474431 | — | IC50 | = | 2187.76 | nM | 5.66 |
| CHEMBL1716544 | — | IC50 | = | 2570.4 | nM | 5.59 |
| CHEMBL1332729 | — | Inhibition | - | % | - | |
| CHEMBL1716544 | — | Inhibition | - | % | - | |
| CHEMBL1374011 | — | Inhibition | - | % | - | |
| CHEMBL1474431 | — | Inhibition | - | % | - |