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Assay Detail

CHEMBL3832780

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Functional
Antimalarial activity: Asexual Blood Stage Plasmodium falciparum W2 IC50 (uM)
ChEMBL ↗
99
Total Activities
99
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364) ↗
Type ORGANISM
Organism Plasmodium falciparum

Publication

MMV Pathogen Box Bioactivity Data
Nathan group, Weill Cornell Medical College; Barry Lab, NIAID NIH; Winzeler lab, UCSD; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Univ. of Antwerp; London School of Hygiene and Tropical Medicine; Parasite Chemotherapy Unit at Swiss Tropical and Public Health Institute; Huston group at the University of Vermont; Castellanos group at UTMB, Galveston, Texas; Sakanari Lab, Univ. of Calif. San Francisco; Townson (Simon) Lab, Imperial College London; Fidelis Cho-Ngwa Lab, University of Buea, Buea, Cameroon; Laboratory of Molecular Parasitology at the New York Blood Center; Bickle Lab, London School of Hygiene and Tropical Medicine; Keiser Lab, Swiss Tropical and Public Health Institute; Caffrey group at the Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego; University of Cape Town; Shanmugam group at CSIR-National Chemical Laboratory, Pune (India); Novartis Institute for Tropical Disease-Singapore; Abbvie

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 99 6.02 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL230001 AZOXYSTROBIN — 1 7.52
CHEMBL587947 — — 1 7.16
CHEMBL528966 — — 1 7.00
CHEMBL601970 — — 1 6.80
CHEMBL598494 — — 1 6.75
CHEMBL531326 — — 1 6.68
CHEMBL525702 — — 1 6.60
CHEMBL528922 — — 1 6.58
CHEMBL532242 — — 1 6.54
CHEMBL546400 — — 1 6.51
CHEMBL534391 — — 1 6.51
CHEMBL604099 — — 1 6.50
CHEMBL2172226 — — 1 6.44
CHEMBL536806 — — 1 6.43
CHEMBL1324287 — — 1 6.43
CHEMBL524742 — — 1 6.40
CHEMBL529152 — — 1 6.38
CHEMBL580702 — — 1 6.33
CHEMBL534395 — — 1 6.31
CHEMBL587161 — — 1 6.29
CHEMBL582027 — — 1 6.27
CHEMBL601821 — — 1 6.27
CHEMBL582507 — — 1 6.24
CHEMBL587715 — — 1 6.23
CHEMBL524204 — — 1 6.22
CHEMBL587139 — — 1 6.21
CHEMBL1197790 — — 1 6.21
CHEMBL267274 — — 1 6.19
CHEMBL3637879 — — 1 6.18
CHEMBL586383 — — 1 6.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL230001 AZOXYSTROBIN IC50 = 30.0 nM 7.52
CHEMBL587947 — IC50 = 70.0 nM 7.16
CHEMBL528966 — IC50 = 100.0 nM 7.00
CHEMBL601970 — IC50 = 160.0 nM 6.80
CHEMBL598494 — IC50 = 180.0 nM 6.75
CHEMBL531326 — IC50 = 210.0 nM 6.68
CHEMBL525702 — IC50 = 250.0 nM 6.60
CHEMBL528922 — IC50 = 260.0 nM 6.58
CHEMBL532242 — IC50 = 290.0 nM 6.54
CHEMBL546400 — IC50 = 310.0 nM 6.51
CHEMBL534391 — IC50 = 310.0 nM 6.51
CHEMBL604099 — IC50 = 320.0 nM 6.50
CHEMBL2172226 — IC50 = 360.0 nM 6.44
CHEMBL1324287 — IC50 = 370.0 nM 6.43
CHEMBL536806 — IC50 = 370.0 nM 6.43
CHEMBL524742 — IC50 = 400.0 nM 6.40
CHEMBL529152 — IC50 = 420.0 nM 6.38
CHEMBL580702 — IC50 = 470.0 nM 6.33
CHEMBL534395 — IC50 = 490.0 nM 6.31
CHEMBL587161 — IC50 = 510.0 nM 6.29
CHEMBL582027 — IC50 = 540.0 nM 6.27
CHEMBL601821 — IC50 = 540.0 nM 6.27
CHEMBL582507 — IC50 = 580.0 nM 6.24
CHEMBL587715 — IC50 = 590.0 nM 6.23
CHEMBL524204 — IC50 = 600.0 nM 6.22
CHEMBL587139 — IC50 = 620.0 nM 6.21
CHEMBL1197790 — IC50 = 620.0 nM 6.21
CHEMBL267274 — IC50 = 640.0 nM 6.19
CHEMBL3637879 — IC50 = 660.0 nM 6.18
CHEMBL586383 — IC50 = 680.0 nM 6.17
CHEMBL526418 — IC50 = 690.0 nM 6.16
CHEMBL532369 — IC50 = 690.0 nM 6.16
CHEMBL536144 — IC50 = 710.0 nM 6.15
CHEMBL530228 — IC50 = 730.0 nM 6.14
CHEMBL1404608 — IC50 = 790.0 nM 6.10
CHEMBL525292 — IC50 = 790.0 nM 6.10
CHEMBL3637881 — IC50 = 800.0 nM 6.10
CHEMBL586872 — IC50 = 790.0 nM 6.10
CHEMBL581971 — IC50 = 820.0 nM 6.09
CHEMBL526214 — IC50 = 850.0 nM 6.07
CHEMBL537372 — IC50 = 860.0 nM 6.07
CHEMBL580816 — IC50 = 880.0 nM 6.06
CHEMBL530887 — IC50 = 890.0 nM 6.05
CHEMBL546977 — IC50 = 910.0 nM 6.04
CHEMBL567341 — IC50 = 940.0 nM 6.03
CHEMBL532350 — IC50 = 970.0 nM 6.01
CHEMBL535286 — IC50 = 990.0 nM 6.00
CHEMBL597266 — IC50 = 1020.0 nM 5.99
CHEMBL529068 — IC50 = 1050.0 nM 5.98
CHEMBL531497 — IC50 = 1050.0 nM 5.98