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Assay Detail

CHEMBL3832789

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
AntiLeishmania activity L. infantum (macrophages) IC50 (uM)
65
Total Activities
65
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania infantum
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania infantum (CHEMBL612848)
Type ORGANISM
Organism Leishmania infantum

Publication

MMV Pathogen Box Bioactivity Data
Nathan group, Weill Cornell Medical College; Barry Lab, NIAID NIH; Winzeler lab, UCSD; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Univ. of Antwerp; London School of Hygiene and Tropical Medicine; Parasite Chemotherapy Unit at Swiss Tropical and Public Health Institute; Huston group at the University of Vermont; Castellanos group at UTMB, Galveston, Texas; Sakanari Lab, Univ. of Calif. San Francisco; Townson (Simon) Lab, Imperial College London; Fidelis Cho-Ngwa Lab, University of Buea, Buea, Cameroon; Laboratory of Molecular Parasitology at the New York Blood Center; Bickle Lab, London School of Hygiene and Tropical Medicine; Keiser Lab, Swiss Tropical and Public Health Institute; Caffrey group at the Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego; University of Cape Town; Shanmugam group at CSIR-National Chemical Laboratory, Pune (India); Novartis Institute for Tropical Disease-Singapore; Abbvie

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 65 5.30 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3637901 1 7.52
CHEMBL3115821 1 6.80
CHEMBL3637900 1 6.33
CHEMBL3431129 1 6.27
CHEMBL3637896 1 6.20
CHEMBL564829 MILCICLIB 2.0 1 6.07
CHEMBL45843 1 6.00
CHEMBL1230468 1 6.00
CHEMBL488436 AZD-5438 1.0 1 5.94
CHEMBL2441383 1 5.85
CHEMBL3431191 1 5.80
CHEMBL227240 1 5.59
CHEMBL3637895 1 5.59
CHEMBL402548 DANUSERTIB 2.0 1 5.39
CHEMBL474899 1 5.39
CHEMBL472881 1 5.39
CHEMBL1836611 1 5.39
CHEMBL238442 1 5.39
CHEMBL3431105 1 5.16
CHEMBL1836562 1 5.00
CHEMBL413331 1 4.99
CHEMBL394241 1 4.99
CHEMBL393580 1 4.87
CHEMBL41 FLUOXETINE 4.0 1 4.87
CHEMBL1683021 1 4.79
CHEMBL511692 1 4.79
CHEMBL3637897 1 4.76
CHEMBL241634 1 4.67
CHEMBL1094051 1 4.59
CHEMBL3546548 1 4.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3637901 IC50 = 30.0 nM 7.52
CHEMBL3115821 IC50 = 160.0 nM 6.80
CHEMBL3637900 IC50 = 470.0 nM 6.33
CHEMBL3431129 IC50 = 540.0 nM 6.27
CHEMBL3637896 IC50 = 630.0 nM 6.20
CHEMBL564829 MILCICLIB IC50 = 850.0 nM 6.07
CHEMBL45843 IC50 = 1010.0 nM 6.00
CHEMBL1230468 IC50 = 1010.0 nM 6.00
CHEMBL488436 AZD-5438 IC50 = 1150.0 nM 5.94
CHEMBL2441383 IC50 = 1410.0 nM 5.85
CHEMBL3431191 IC50 = 1590.0 nM 5.80
CHEMBL227240 IC50 = 2540.0 nM 5.59
CHEMBL3637895 IC50 = 2540.0 nM 5.59
CHEMBL238442 IC50 = 4060.0 nM 5.39
CHEMBL474899 IC50 = 4030.0 nM 5.39
CHEMBL472881 IC50 = 4060.0 nM 5.39
CHEMBL402548 DANUSERTIB IC50 = 4060.0 nM 5.39
CHEMBL1836611 IC50 = 4060.0 nM 5.39
CHEMBL3431105 IC50 = 6870.0 nM 5.16
CHEMBL1836562 IC50 = 10120.0 nM 5.00
CHEMBL413331 IC50 = 10160.0 nM 4.99
CHEMBL394241 IC50 = 10160.0 nM 4.99
CHEMBL393580 IC50 = 13630.0 nM 4.87
CHEMBL41 FLUOXETINE IC50 = 13630.0 nM 4.87
CHEMBL511692 IC50 = 16230.0 nM 4.79
CHEMBL1683021 IC50 = 16230.0 nM 4.79
CHEMBL3637897 IC50 = 17280.0 nM 4.76
CHEMBL241634 IC50 = 21530.0 nM 4.67
CHEMBL1094051 IC50 = 25400.0 nM 4.59
CHEMBL3546548 IC50 = 32000.0 nM 4.50
CHEMBL1515447 HOMOCHLORCYCLIZINE IC50 = 36320.0 nM 4.44
CHEMBL3431084 IC50 = 44020.0 nM 4.36
CHEMBL466426 DIFENOCONAZOLE IC50 = 44700.0 nM 4.35
CHEMBL2229099 TOLFENPYRAD IC50 = 45630.0 nM 4.34
CHEMBL1308225 IC50 = 50380.0 nM 4.30
CHEMBL3546405 IC50 = 52200.0 nM 4.28
CHEMBL1683016 IC50 > 32000.0 nM -
CHEMBL394474 IC50 > 32000.0 nM -
CHEMBL519040 IC50 > 32000.0 nM -
CHEMBL458799 IC50 > 32000.0 nM -
CHEMBL472854 IC50 > 32000.0 nM -
CHEMBL1197563 IC50 > 32000.0 nM -
CHEMBL3637892 IC50 > 32000.0 nM -
CHEMBL3431166 IC50 > 64000.0 nM -
CHEMBL227667 IC50 > 32000.0 nM -
CHEMBL3431223 IC50 > 64000.0 nM -
CHEMBL241427 IC50 > 32000.0 nM -
CHEMBL3637893 IC50 > 32000.0 nM -
CHEMBL3637894 IC50 > 32000.0 nM -
CHEMBL3431063 IC50 > 64000.0 nM -