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Assay Detail

CHEMBL3832791

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
AntiLeishmania activity L. donovani (macrophages) IC50 (uM)
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

MMV Pathogen Box Bioactivity Data
Nathan group, Weill Cornell Medical College; Barry Lab, NIAID NIH; Winzeler lab, UCSD; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Univ. of Antwerp; London School of Hygiene and Tropical Medicine; Parasite Chemotherapy Unit at Swiss Tropical and Public Health Institute; Huston group at the University of Vermont; Castellanos group at UTMB, Galveston, Texas; Sakanari Lab, Univ. of Calif. San Francisco; Townson (Simon) Lab, Imperial College London; Fidelis Cho-Ngwa Lab, University of Buea, Buea, Cameroon; Laboratory of Molecular Parasitology at the New York Blood Center; Bickle Lab, London School of Hygiene and Tropical Medicine; Keiser Lab, Swiss Tropical and Public Health Institute; Caffrey group at the Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego; University of Cape Town; Shanmugam group at CSIR-National Chemical Laboratory, Pune (India); Novartis Institute for Tropical Disease-Singapore; Abbvie

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.06 5.58

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL472881 1 5.58
CHEMBL474899 1 5.38
CHEMBL511692 1 5.29
CHEMBL1683021 1 4.89
CHEMBL1094051 1 4.65
CHEMBL394474 1 4.58
CHEMBL394241 1 -
CHEMBL1683016 1 -
CHEMBL458799 1 -
CHEMBL472854 1 -
CHEMBL3637892 1 -
CHEMBL1197563 1 -
CHEMBL519040 1 -
CHEMBL241634 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL472881 IC50 = 2600.0 nM 5.58
CHEMBL474899 IC50 = 4200.0 nM 5.38
CHEMBL511692 IC50 = 5170.0 nM 5.29
CHEMBL1683021 IC50 = 12800.0 nM 4.89
CHEMBL1094051 IC50 = 22200.0 nM 4.65
CHEMBL394474 IC50 = 26100.0 nM 4.58
CHEMBL394241 IC50 > 10000.0 nM -
CHEMBL1683016 IC50 > 30000.0 nM -
CHEMBL458799 IC50 > 30000.0 nM -
CHEMBL472854 IC50 > 30000.0 nM -
CHEMBL3637892 IC50 > 30000.0 nM -
CHEMBL1197563 IC50 > 30000.0 nM -
CHEMBL519040 IC50 > 30000.0 nM -
CHEMBL241634 IC50 > 30000.0 nM -