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Assay Detail

CHEMBL3832807

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
AntiOnchocerca activity O. volvulus L3 Molting assay: IC50 (uM)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Onchocerca volvulus
Confidence 1 — Organism
Curated By Autocuration

Target

Onchocerca volvulus (CHEMBL613142)
Type ORGANISM
Organism Onchocerca volvulus

Publication

MMV Pathogen Box Bioactivity Data
Nathan group, Weill Cornell Medical College; Barry Lab, NIAID NIH; Winzeler lab, UCSD; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Univ. of Antwerp; London School of Hygiene and Tropical Medicine; Parasite Chemotherapy Unit at Swiss Tropical and Public Health Institute; Huston group at the University of Vermont; Castellanos group at UTMB, Galveston, Texas; Sakanari Lab, Univ. of Calif. San Francisco; Townson (Simon) Lab, Imperial College London; Fidelis Cho-Ngwa Lab, University of Buea, Buea, Cameroon; Laboratory of Molecular Parasitology at the New York Blood Center; Bickle Lab, London School of Hygiene and Tropical Medicine; Keiser Lab, Swiss Tropical and Public Health Institute; Caffrey group at the Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego; University of Cape Town; Shanmugam group at CSIR-National Chemical Laboratory, Pune (India); Novartis Institute for Tropical Disease-Singapore; Abbvie

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 5.78 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3637912 1 5.96
CHEMBL3637907 1 5.87
CHEMBL3637908 1 5.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3637912 IC50 = 1090.0 nM 5.96
CHEMBL3637907 IC50 = 1340.0 nM 5.87
CHEMBL3637908 IC50 = 3130.0 nM 5.50