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Assay Detail

CHEMBL3832809

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
AntiSchistosoma mansoni activity Larva IC50 (uM)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Schistosoma mansoni
Confidence 1 — Organism
Curated By Autocuration

Target

Schistosoma mansoni (CHEMBL612893)
Type ORGANISM
Organism Schistosoma mansoni

Publication

MMV Pathogen Box Bioactivity Data
Nathan group, Weill Cornell Medical College; Barry Lab, NIAID NIH; Winzeler lab, UCSD; Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Univ. of Antwerp; London School of Hygiene and Tropical Medicine; Parasite Chemotherapy Unit at Swiss Tropical and Public Health Institute; Huston group at the University of Vermont; Castellanos group at UTMB, Galveston, Texas; Sakanari Lab, Univ. of Calif. San Francisco; Townson (Simon) Lab, Imperial College London; Fidelis Cho-Ngwa Lab, University of Buea, Buea, Cameroon; Laboratory of Molecular Parasitology at the New York Blood Center; Bickle Lab, London School of Hygiene and Tropical Medicine; Keiser Lab, Swiss Tropical and Public Health Institute; Caffrey group at the Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego; University of Cape Town; Shanmugam group at CSIR-National Chemical Laboratory, Pune (India); Novartis Institute for Tropical Disease-Singapore; Abbvie

· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 7 5.67 6.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3637922 1 6.54
CHEMBL3637918 1 6.30
CHEMBL3637915 1 5.85
CHEMBL3637924 1 5.47
CHEMBL3637916 1 5.18
CHEMBL3637917 1 5.17
CHEMBL3637919 1 5.17

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3637922 IC50 = 290.0 nM 6.54
CHEMBL3637918 IC50 = 500.0 nM 6.30
CHEMBL3637915 IC50 = 1400.0 nM 5.85
CHEMBL3637924 IC50 = 3360.0 nM 5.47
CHEMBL3637916 IC50 = 6600.0 nM 5.18
CHEMBL3637917 IC50 = 6700.0 nM 5.17
CHEMBL3637919 IC50 = 6700.0 nM 5.17