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Assay Detail

CHEMBL3853648

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Activity at NET in rat synaptosomes obtained from whole brain minus striatum and cerebellum assessed as release of [3H]MPP+ by liquid scintillation counting method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Medchemcomm (2016) 7 : 1657 -1663
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 13 6.67 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL612 DEXTROAMPHETAMINE 4.0 1 8.15
CHEMBL471839 1 7.96
CHEMBL3921422 1 6.86
CHEMBL3963971 1 6.77
CHEMBL3896023 1 6.68
CHEMBL3982376 1 6.62
CHEMBL3913053 1 6.55
CHEMBL3965276 1 6.52
CHEMBL3933915 1 6.51
CHEMBL3912463 1 6.30
CHEMBL3930376 1 6.21
CHEMBL3974905 1 6.11
CHEMBL3945529 1 5.53

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL612 DEXTROAMPHETAMINE EC50 = 7.1 nM 8.15
CHEMBL471839 EC50 = 11.1 nM 7.96
CHEMBL3921422 EC50 = 138.0 nM 6.86
CHEMBL3963971 EC50 = 170.0 nM 6.77
CHEMBL3896023 EC50 = 211.0 nM 6.68
CHEMBL3982376 EC50 = 239.0 nM 6.62
CHEMBL3913053 EC50 = 279.0 nM 6.55
CHEMBL3965276 EC50 = 301.0 nM 6.52
CHEMBL3933915 EC50 = 308.0 nM 6.51
CHEMBL3912463 EC50 = 496.0 nM 6.30
CHEMBL3930376 EC50 = 621.0 nM 6.21
CHEMBL3974905 EC50 = 784.0 nM 6.11
CHEMBL3945529 EC50 = 2980.0 nM 5.53