Assay Detail
Binding
CHEMBL3853686
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Non-competitive inhibition of jack bean beta-N-acetylglucosaminidase using p-nitrophenyl-N-acetyl-beta-D-glucosamide as substrate at pH 5.5 incubated for 10 to 30 mins by Linerweaver-Burk plot/double reciprocal plot analysis
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Canavalia ensiformis |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Efficient stereoselective synthesis of 2-acetamido-1,2-dideoxyallonojirimycin (DAJNAc) and sp(2)-iminosugar conjugates: Novel hexosaminidase inhibitors with discrimination capabilities between the mature and precursor forms of the enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 4.94 | 5.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3983808 | — | — | 1 | 5.64 |
| CHEMBL3966025 | — | — | 1 | 5.58 |
| CHEMBL3932594 | — | — | 1 | 5.02 |
| CHEMBL3895004 | — | — | 1 | 4.87 |
| CHEMBL3982827 | — | — | 1 | 4.70 |
| CHEMBL3955165 | — | — | 1 | 4.63 |
| CHEMBL3936181 | — | — | 1 | 4.12 |
| CHEMBL3933402 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3983808 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL3966025 | — | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL3932594 | — | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL3895004 | — | Ki | = | 13400.0 | nM | 4.87 |
| CHEMBL3982827 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL3955165 | — | Ki | = | 23600.0 | nM | 4.63 |
| CHEMBL3936181 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL3933402 | — | Ki | = | 363000.0 | nM | - |